PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Palmieri D, Valentino T, De Martino I, Esposito F, Cappabianca P, Wierinckx A, Vitiello M, Lombardi G, Colao A, Trouillas J, Pierantoni GM, Fusco A, Fedele M.
Palmieri D, et al.
Endocr Relat Cancer. 2012 Apr 10;19(2):123-35. doi: 10.1530/ERC-11-0135. Print 2012 Apr.
Endocr Relat Cancer. 2012.
PMID: 22199144
We have previously demonstrated that HMGA1B and HMGA2 overexpression in mice induces the development of GH and prolactin (PRL) pituitary adenomas mainly by increasing E2F1 transcriptional activity. Interestingly, these adenomas showed very high expression levels of PIT1, a …
We have previously demonstrated that HMGA1B and HMGA2 overexpression in mice induces the development of GH and prolactin (PRL) pituit …